TA107 Breast cancer (early) - trastuzumab: quick reference guide

The quick reference guide on trastuzumab (herceptin) for the adjuvant treatment of early-stage HER2-positive breast cancer presents recommendations in a suitable format for health professionals.

Correction

It has been brought to our attention that this guidance contained an error in section 1.3, where it stated that:

‘Cardiac functional assessments should be repeated every 3 months during trastuzumab treatment. If the LVEF drops by 10% from baseline and to below 50% then trastuzumab treatment should be suspended…’

This has now been amended so that it follows more closely the SPC for trastuzumab, as follows:

‘Cardiac functional assessments should be repeated every 3 months during trastuzumab treatment. If the LVEF drops by 10 percentage (ejection) points or more from baseline and to below 50% then trastuzumab treatment should be suspended…’

Electronic versions of the guidance have been amended below. Printed copies of the amended quick reference guide will be available shortly from the NHS Response Line; telephone 0870 1555 455 and quote reference number N1111.