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Diabetes - liraglutide

Liraglutide for the treatment of type 2 diabetes

Status: In progress
Expected date of issue: TBC
Referral date: November 2008
Wave: 20
Process: STA
Topic area:
  • Endocrine, nutritional and metabolic
 

NICE project team

Executive Lead: Andrew Dillion
Technical Lead: Carina Righetti
Communications manager: Gregory Jones
Project manager: Bijal Joshi
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Provisional schedule

Closing date for invited submissions / evidence submission: 5 October 2009
1st appraisal committee meeting: 19 January 2010
2nd appraisal committee meeting 20 April 2010
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Consultees and Commentators

Consultees Commentators (no right to submit or appeal)

Manufacturers / Sponsors

  • Novo Nordisk (liraglutide)

Patient / carer Groups

  • Afiya Trust
  • Age Concern & Help the Aged
  • Black & Ethnic Minority Diabetes Association (BEMDA)
  • Black Health Agency
  • Chinese National Healthy Living Centre
  • Confederation of Indian Organisations
  • Counsel and Care
  • Diabetes Research & Wellness Foundation
  • Diabetes UK
  • Equalities National Council
  • Muslim Council of Great Britain
  • Muslim Health Network
  • National Obesity Forum (Added – 30/9/09)
  • Network of Sikh Organisations
  • South Asian Health Foundation
  • Specialised Healthcare Alliance
  • Surya Foundation

Professional groups

  • Association of British Clinical Diabetologists
  • British Association for Services to the Elderly
  • British Geriatrics Society
  • Diabetes Monitoring Forum
  • National Diabetes Nurse Consultant Group (previously Association of Diabetes Specialist Nurses – 19/8/09)
  • Primary Care Diabetes UK
  • Royal College of General Practitioners
  • Royal College of Nursing
  • Royal College of Pathologists
  • Royal Collegeof Physicians
  • Royal Pharmaceutical Society
  • Royal Society of Medicine – Intellectual Disabilities Forum
  • United Kingdom Clinical Pharmacy Association
  • British Diabetics Association (removed – same as Diabetes UK – 19/8/09)

Others

  • Department of Health
  • NorfolkPCT
  • Welsh Assembly Government
  • West SussexTeaching PCT

General

  • Board of Community Health Councils in Wales
  • British National Formulary
  • Diabetes UK Cymru
  • Department of Health, Social Services and Public Safety for Northern Ireland
  • Medicines and Healthcare products Regulatory Agency (MHRA)
  • National Association of Primary Care
  • National Public Health Service for Wales
  • NHS Alliance
  • NHS Confederation
  • NHS Purchasing and Supply Agency
  • NHS Quality Improvement Scotland
  • Scottish Medicines Consortium

Comparator manufacturer(s)

  • Actavis UK (gliclazide)
  • Actavis (glimepiride, tolbutamide)
  • Daiichi-Sankyo (repaglinide)
  • Eli Lilly (exenatide)
  • GSK (metformin/rosiglitazone, rosiglitazone)
  • Hoechst Marion Roussel (glimepiride)
  • Lilly (Humulin, Humalog)
  • Merck (metformin)
  • Merck, Sharp and Dohme (sitagliptin)
  • Novartis (metformin, vildagliptin, nateglinide)
  • Novo Nordisk (Actrapid, Velosulin, Novorapid, Levemir, Insulatard, NovoMix, Mixtard)
  • Pfizer (glipizide)
  • Rosemont Pharmaceuticals(metformin)
  • Sanofi-aventis (Apidra, gliquidone, glibenclamide, glimepiride, Insuman, Lantus)
  • Servier (gliclazide)
  • Takeda (metformin, pioglitazone)
  • Wockhardt (metformin,Hypurin, glibenclamide)

Relevant research groups

  • Diabetes Foundation
  • Heart Disease & Diabetes Research Trust
  • MRC Clinical Trials Unit
  • National Institute for Health Research
  • Policy Research Institute on Ageing and Ethnicity
  • Research Institute for the Care of Older People

Evidence Review Group

  • Aberdeen HTA Group
  • National Institute for Health Research Health Technology Assessment Programme

Associated Guideline Groups

  • None

Associated Public Health Groups

  • None

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Project history

Date Update
11 March 2010

The consultation on the provisional guidance for liraglutide in type 2 diabetes closed on 5th March. As you are aware, the Committee recommended that NICE requests further clarification from the manufacturer of liraglutide (Novo Nordisk), with respect to the use of liraglutide in dual therapy regimens.

Novo Nordisk submitted a response to the request for further clarification but also supplied further analyses over and above those requested.

In accordance with the guide to the single technology appraisal process (section 3.5.34), NICE will have to extend the timelines for this appraisal to allow for a full and comprehensive review of new evidence. The second discussion of this topic will now take place on 20 April 2010

   
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Key documents

This page was last updated:   11 March 2010