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Extracorporeal albumin dialysis for acute-on-chronic liver failure

Guidance issued Guidance issued
 
IP Guidance Number: IPG45
 
Summary:

The National Institute for Health and Clinical Excellence (NICE) has issued full guidance to the NHS in England, Wales, Scotland and Northern Ireland on extracoropreal albumin dialysis for acute-on-chronic-liver failure.

Description:

Extracorporeal albumin dialysis for acute-on-chronic liver failure involves pumping blood from the body through a thin membrane coated with albumin. Molecules that bind to the albumin membrane are then removed by passing through a charcoal column and an anion exchange, before being reintroduced into the circuit. Both water-soluble toxins (as in renal dialysis) and strongly albumin-bound toxins are removed by this process.

Albumin is purported to have important transport and detoxifications functions, such as the removal of albumin-bound substances, which may ameliorate some of the problems of liver failure.

Arrangements:

Special

Topic Area:

Digestive system
Therapeutic procedures

Specialty:

Gastro-enterology

Specialist advice has
been sought from:
Date notified to NICE: 14 April 2003
Guidance Publication Date: 25 February 2004
Contact Details:
Project Manager
(for general enquiries or comments)
Ben Doak
ip@nice.org.uk
Technical Lead
(for procedure specific enquiries or comments)
Sally Wortley
ip@nice.org.uk
Contact Address:

Interventional Procedures Programme
National Institute for Health and Clinical Excellence
MidCity Place
71 High Holborn
London
WC1V 6NA


Links:

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