Photodynamic therapy for non-melanoma skin tumours (including premalignant and primary non-metastatic skin lesions)
Summary
The National Institute for Health and Clinical Excellence (NICE) has issued full guidance to the NHS in England, Wales, Scotland and Northern Ireland on photodynamic therapy for non-melanoma skin tumours (including premalignant and primary non-metastatic skin lesions).
Description
Non-melanoma skin tumours include basal cell carcinoma, squamous cell carcinoma, Bowen's disease and actinic (or solar) keratoses.
Current treatments for basal cell carcinoma include topical chemotherapy, curettage, surgical excision, cryotherapy and radiotherapy. Squamous cell carcinoma is usually removed surgically. Actinic keratoses and Bowen's disease are usually treated with curettage, cryotherapy or topical chemotherapy.
Before photodynamic therapy (PDT), the lesion is prepared by removing overlying crust and scale. Cream containing a photosensitising agent is applied to the lesion and a margin of surrounding skin. The area is covered with a light occlusive dressing and left for a few hours. Excess cream is then removed and the lesion is illuminated by light of an appropriate wavelength to activate the photosensitiser, producing targeted tumour destruction. Occasionally, the photosensitising agent may be given intravenously. More than one lesion may be treated in a session and the treatment may be repeated.
OPCS code:
Details
Skin
Surgical procedures
British Association of Dermatologists
British Association of Plastic Surgeons
Contact details:
(for general enquiries or comments)
(for procedure specific enquiries or comments)
ip@nice.org.uk
Interventional Procedures Programme
National Institute for Health and Clinical Excellence
MidCity Place
71 High Holborn
London
WC1V 6NA
