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Pancreatic islet cell transplantation

Guidance issued Guidance issued
 
Number: IPG13
 
Summary:

NICE's guidance on pancreatic islet cell transplantation has now been superceded.

Please go to www.nice.org.uk/ipg257 to view the full guidance on allogeneic pancreatic islet cell transplantation for type 1 diabetes mellitus and to www.nice.org.uk/ipg274 to view the full guidance on autologous pancreatic islet cell transplantation for improved glycaemic control after pancreatectomy issued to the NHS in England, Wales, Scotland and Northern Ireland.

Description:

Pancreatic islet cell transplantation is used in people whose bodies cannot make insulin (or cannot make as much of it as they need). This could be because they have a form of diabetes known as type 1. Or it could be because they have had their pancreas removed as a treatment for pancreatitis. Insulin is important for controlling the balance of sugar in the body. It is made in special cells in the pancreas called islet cells.

With pancreatic islet cell transplantation, a person's islet cells are replaced with islet cells from a human donor. In some cases, it's possible to use islet cells from the person's own pancreas. These islet cells are usually put into the person's liver. If the procedure is successful, the cells re-start making insulin. Medicines called immunosuppressants often have to be taken to protect donor cells from being attacked by the person's immune system.

The usual treatment for people with type 1 diabetes and those who've had their pancreas removed is regular injections of insulin.

Arrangement:

Other (see guidance)

Topic Area:

Digestive system
Endocrine, nutritional and metabolic
Surgical procedures

Specialty:

Gastroenterology

Specialist advice has been sought from: British Transplantation Society
Date notified to NICE: 01 April 2002
IP Pub Date: 22 October 2003
Contact Details:
Project manager (for general enquiries or comments)
(for general enquiries or comments)
Ben Doak
Contact Address:

Interventional Procedures Programme
National Institute for Health and Clinical Excellence
MidCity Place
71 High Holborn
London
WC1V 6NA


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